Can you provide evidence that each Amplify ingredient extends lifespan and/or improves healthspan in animal models?Updated 6 months ago
Berberine:
Dang et al. Berberine ameliorates cellular senescence and extends the lifespan of mice via regulating p16 and cyclin protein expression. Aging Cell 2020. https://doi.org/10.1111%2Facel.13060
Yu et al. Berberine Improves Cognitive Deficiency and Muscular Dysfunction via Activation of the AMPK/SIRT1/PGC-1a Pathway in Skeletal Muscle from Naturally Aging Rats. The Journal of Nutrition, Health, & Aging 2018; https://doi.org/10.1007/s12603-018-1015-7
Durairajan et al. Berberine ameliorates β-amyloid pathology, gliosis, and cognitive impairment in an Alzheimer's disease transgenic mouse model. Neurobiology of Aging 2012; https://doi.org/10.1016/j.neurobiolaging.2012.02.016
Li et al. Berberine Ameliorates Obesity by Inducing GDF15 Secretion by Brown Adipocytes. Endocrinology 2023; https://doi.org/10.1210/endocr/bqad035
Glycine:
Miller et al. Glycine supplementation extends lifespan of male and female mice. Aging Cell 2019; https://doi.org/10.1111/acel.12953
Brind et al. Dietary glycine supplementation mimics lifespan extension by dietary methionine restriction in Fisher 344 rats. The FASEB Journal 2011; https://doi.org/10.1096/fasebj.25.1_supplement.528.2
Chen et al. Dietary Supplementation with Glycine Enhances Intestinal Mucosal Integrity and Ameliorates Inflammation in C57BL/6J Mice with High-Fat Diet-Induced Obesity. The Journal of Nutrition 2021; https://doi.org/10.1093/jn/nxab058
Ullah et al. Glycine, the smallest amino acid, confers neuroprotection against D-galactose-induced neurodegeneration and memory impairment by regulating c-Jun N-terminal kinase in the mouse brain. Journal of Neuroinflammation 2020; https://doi.org/10.1186/s12974-020-01989-w
Coenzyme Q10:
Yan et al. Reduced coenzyme Q10 supplementation decelerates senescence in SAMP1 mice. Experimental Gerontology 2006; https://doi.org/10.1016/j.exger.2005.11.007
Takahashi and Takahashi. Exogenous administration of coenzyme Q10 restores mitochondrial oxygen consumption in the aged mouse brain. Mechanisms of Ageing and Development 2013; https://doi.org/10.1016/j.mad.2013.11.010
Quiles et al. Coenzyme Q supplementation protects from age-related DNA double-strand breaks and increases lifespan in rats fed on a PUFA-rich diet. Experimental Gerontology 2004; https://doi.org/10.1016/j.exger.2003.10.002
Yang et al. Coenzyme Q10 attenuates beta-amyloid pathology in the aged transgenic mice with Alzheimer presenilin 1 mutation. Journal of Molecular Neuroscience 2008; https://doi.org/10.1007/s12031-007-9033-7