Can you provide evidence that each Amplify ingredient extends lifespan and/or improves healthspan in animal models?Updated 2 months ago

Berberine:

• Dang et al. Berberine ameliorates cellular senescence and extends the lifespan of mice via regulating p16 and cyclin protein expression. Aging Cell 2020. https://doi.org/10.1111%2Facel.13060
• Yu et al. Berberine Improves Cognitive Deficiency and Muscular Dysfunction via Activation of the AMPK/SIRT1/PGC-1a Pathway in Skeletal Muscle from Naturally Aging Rats. The Journal of Nutrition, Health, & Aging 2018; https://doi.org/10.1007/s12603-018-1015-7
• Durairajan et al. Berberine ameliorates β-amyloid pathology, gliosis, and cognitive impairment in an Alzheimer's disease transgenic mouse model. Neurobiology of Aging 2012; https://doi.org/10.1016/j.neurobiolaging.2012.02.016

Glycine:

• Miller et al. Glycine supplementation extends lifespan of male and female mice. Aging Cell 2019; https://doi.org/10.1111/acel.12953
• Brind et al. Dietary glycine supplementation mimics lifespan extension by dietary methionine restriction in Fisher 344 rats. The FASEB Journal 2011; https://doi.org/10.1096/fasebj.25.1_supplement.528.2
• Chen et al. Dietary Supplementation with Glycine Enhances Intestinal Mucosal Integrity and Ameliorates Inflammation in C57BL/6J Mice with High-Fat Diet-Induced Obesity. The Journal of Nutrition 2021; https://doi.org/10.1093/jn/nxab058

Urolithin A:

• Ryu et al. Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents. Nature Medicine 2016; https://doi.org/10.1038/nm.4132
• Xia et al. Urolithin A exerts antiobesity effects through enhancing adipose tissue thermogenesis in mice. PLoS Biology 2020; https://doi.org/10.1371/journal.pbio.3000688
• Ghosh et al. Urolithin A augments angiogenic pathways in skeletal muscle by bolstering NAD+ and SIRT1. Scientific Reports 2020; https://doi.org/10.1038/s41598-020-76564-7