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Can you provide evidence that each Amplify ingredient extends lifespan and/or improves healthspan in animal models?Updated 10 days ago

Berberine: activates the pro-longevity AMPK signaling pathway, an essential energy sensor used by our cells. Several studies have shown berberine lowers blood sugar, augments insulin secretion, and improves metabolic health in humans. Berberine is only found naturally in a handful of herbs and plants infrequently eaten by humans, making Amplify™ an efficient way to obtain this amazing molecule.

  • Dang et al. Berberine ameliorates cellular senescence and extends the lifespan of mice via regulating p16 and cyclin protein expression. Aging Cell 2020. https://doi.org/10.1111%2Facel.13060

  • Yu et al. Berberine Improves Cognitive Deficiency and Muscular Dysfunction via Activation of the AMPK/SIRT1/PGC-1a Pathway in Skeletal Muscle from Naturally Aging Rats. The Journal of Nutrition, Health, & Aging 2018; https://doi.org/10.1007/s12603-018-1015-7

  • Durairajan et al. Berberine ameliorates β-amyloid pathology, gliosis, and cognitive impairment in an Alzheimer's disease transgenic mouse model. Neurobiology of Aging 2012; https://doi.org/10.1016/j.neurobiolaging.2012.02.016

Glycine: In addition to extending lifespan and improving health in many different animals, including mice and rats, current evidence suggests that glycine mimics the benefits of caloric restriction by helping to clear out the pro-aging amino acid methionine.

Urolithin A: By inducing mitophagy, the selective recycling of dysfunctional mitochondria, urolithin A helps keep our cellular power plants functional and productive. Research in mice shows that urolithin A increases NAD+ levels in muscle, which is quite interesting given the evidence that this molecule boosts muscle function in both mice and humans.

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