Can you provide evidence that each Amplify ingredient extends lifespan and/or improves healthspan in animal models?Updated a month ago
Berberine: activates the pro-longevity AMPK signaling pathway, an essential energy sensor used by our cells. Several studies have shown berberine lowers blood sugar, augments insulin secretion, and improves metabolic health in humans. Berberine is only found naturally in a handful of herbs and plants infrequently eaten by humans, making Amplify™ an efficient way to obtain this amazing molecule.
Dang et al. Berberine ameliorates cellular senescence and extends the lifespan of mice via regulating p16 and cyclin protein expression. Aging Cell 2020. https://doi.org/10.1111%2Facel.13060
Yu et al. Berberine Improves Cognitive Deficiency and Muscular Dysfunction via Activation of the AMPK/SIRT1/PGC-1a Pathway in Skeletal Muscle from Naturally Aging Rats. The Journal of Nutrition, Health, & Aging 2018; https://doi.org/10.1007/s12603-018-1015-7
Durairajan et al. Berberine ameliorates β-amyloid pathology, gliosis, and cognitive impairment in an Alzheimer's disease transgenic mouse model. Neurobiology of Aging 2012; https://doi.org/10.1016/j.neurobiolaging.2012.02.016
Glycine: In addition to extending lifespan and improving health in many different animals, including mice and rats, current evidence suggests that glycine mimics the benefits of caloric restriction by helping to clear out the pro-aging amino acid methionine.
Miller et al. Glycine supplementation extends lifespan of male and female mice. Aging Cell 2019; https://doi.org/10.1111/acel.12953
Brind et al. Dietary glycine supplementation mimics lifespan extension by dietary methionine restriction in Fisher 344 rats. The FASEB Journal 2011; https://doi.org/10.1096/fasebj.25.1_supplement.528.2
Chen et al. Dietary Supplementation with Glycine Enhances Intestinal Mucosal Integrity and Ameliorates Inflammation in C57BL/6J Mice with High-Fat Diet-Induced Obesity. The Journal of Nutrition 2021; https://doi.org/10.1093/jn/nxab058
Urolithin A: By inducing mitophagy, the selective recycling of dysfunctional mitochondria, urolithin A helps keep our cellular power plants functional and productive. Research in mice shows that urolithin A increases NAD+ levels in muscle, which is quite interesting given the evidence that this molecule boosts muscle function in both mice and humans.
Ryu et al. Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents. Nature Medicine 2016; https://doi.org/10.1038/nm.4132
Xia et al. Urolithin A exerts antiobesity effects through enhancing adipose tissue thermogenesis in mice. PLoS Biology 2020; https://doi.org/10.1371/journal.pbio.3000688
Ghosh et al. Urolithin A augments angiogenic pathways in skeletal muscle by bolstering NAD+ and SIRT1. Scientific Reports 2020; https://doi.org/10.1038/s41598-020-76564-7