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Can you provide evidence that each Restore ingredient improves sleep and extends lifespan and/or improves healthspan in animal models?Updated a month ago

Magnesium bisglycinate:

  • Mah, J., Pitre, T. Oral magnesium supplementation for insomnia in older adults: a Systematic Review & Meta-Analysis. BMC Complement Med Ther 21, 125 (2021). https://doi.org/10.1186/s12906-021-03297-z

  • Yijia Zhang, Cheng Chen, Liping Lu, Kristen L Knutson, Mercedes R Carnethon, Alyce D Fly, Juhua Luo, David M Haas, James M Shikany, Ka Kahe, Association of magnesium intake with sleep duration and sleep quality: findings from the CARDIA study, Sleep, Volume 45, Issue 4, April 2022, zsab276, https://doi.org/10.1093/sleep/zsab276

  • Villa-Bellosta R. Dietary magnesium supplementation improves lifespan in a mouse model of progeria. EMBO Mol Med. 2020 Oct 7;12(10):e12423. doi: 10.15252/emmm.202012423. Epub 2020 Aug 16. PMID: 32875720; PMCID: PMC7539193.


L-theanine: 

  • Lyon MR, Kapoor MP, Juneja LR. The effects of L-theanine (Suntheanine®) on objective sleep quality in boys with attention deficit hyperactivity disorder (ADHD): a randomized, double-blind, placebo-controlled clinical trial. Altern Med Rev. 2011 Dec;16(4):348-54. PMID: 22214254.

  • Hidese S, Ogawa S, Ota M, Ishida I, Yasukawa Z, Ozeki M, Kunugi H. Effects of L-Theanine Administration on Stress-Related Symptoms and Cognitive Functions in Healthy Adults: A Randomized Controlled Trial. Nutrients. 2019; 11(10):2362. https://doi.org/10.3390/nu11102362

  • Zarse, K., Jabin, S. & Ristow, M. L-Theanine extends lifespan of adult Caenorhabditis elegans . Eur J Nutr51, 765–768 (2012). https://doi.org/10.1007/s00394-012-0341-5


Apigenin: 

  • Godos J, Ferri R, Castellano S, Angelino D, Mena P, Del Rio D, Caraci F, Galvano F, Grosso G. Specific Dietary (Poly)phenols Are Associated with Sleep Quality in a Cohort of Italian Adults. Nutrients. 2020; 12(5):1226. https://doi.org/10.3390/nu12051226

  • Zanoli P, Avallone R, Baraldi M. Behavioral characterisation of the flavonoids apigenin and chrysin. Fitoterapia. 2000 Aug;71 Suppl 1:S117-23. doi: 10.1016/s0367-326x(00)00186-6. PMID: 10930722.

  • Jay D. Amsterdam, Qing S. Li, Sharon X. Xie, and Jun J. Mao. Putative Antidepressant Effect of Chamomile (Matricaria chamomilla L.) Oral Extract in Subjects with Comorbid Generalized Anxiety Disorder and Depression. The Journal of Alternative and Complementary Medicine.Sep 2020.815-821. http://doi.org/10.1089/acm.2019.0252

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